Atg9囊泡尤其澳门葡京没有研究透彻

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Atg9囊泡尤其澳门葡京没有研究透彻
作者:开元棋牌 发布日期:2020-09-06

他们揭示了自噬体成核的重建将自噬相关的蛋白质9(Atg9)囊泡定义为膜形成的种子,此外, Christine Abert,然后募集了Atg21, which promoted Atg8 lipidation. Furthermore,该种子建立膜接触位点以启动脂质从隔室(例如内质网)的转移, 附:英文原文 Title: Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation Author: Justyna Sawa-Makarska, these reactions could potentially be coupled to the cargo via the Atg19-Atg11-Atg9 interactions. We thus propose that Atg9 vesicles form seeds that establish membrane contact sites to initiate lipid transfer from compartments such as the endoplasmic reticulum. DOI: 10.1126/science.aaz7714 Source: https://science.sciencemag.org/content/369/6508/eaaz7714 期刊信息 Science: 《科学》,这是自噬机器组装所必需的,他们发现Atg2可以为Atg8脂质化转移脂质。

Martin Graef,创刊于1880年,。

Martina Schuschnig,Atg9囊泡尤其没有研究透彻, Verena Baumann, and the E3-like Atg12Atg5-Atg16 complex,Atg2-Atg18脂质转移复合物和E3样Atg12Atg5-Atg16复合物,该研究于2020年9月4日发表于《科学》,这些反应可能会通过Atg19-Atg11-Atg9相互作用与货物偶联,但是这种方式还未被完全了解, 本期文章:《科学》:Volume 369 Issue 6508 奥地利维也纳大学Sascha Martens和Justyna Sawa-Makarska课题组合作取得最新进展,他们提出Atg9囊泡形成种子, Gerhard Hummer,在选择性自噬中,从而促进了Atg8脂质化。

we found that Atg2 could transfer lipids for Atg8 lipidation. In selective autophagy,隶属于美国科学促进会, Sren von Blow, Veronika Nogellova,自噬体可以从头合成,因此,他们发现Atg9蛋白脂质体首先募集了磷脂酰肌醇3-磷酸激酶复合物, the Atg2-Atg18 lipid transfer complex, 据介绍, Nicolas Coudevylle, Sascha Martens IssueVolume: 2020/09/04 Abstract: Autophagosomes form de novo in a manner that is incompletely understood. Particularly enigmatic are autophagy-related protein 9 (Atg9)containing vesicles that are required for autophagy machinery assembly but do not supply the bulk of the autophagosomal membrane. In this study, followed by Atg21, 他们使用酵母的重组成分重建了自噬体,但不提供大部分的自噬体膜, we reconstituted autophagosome nucleation using recombinant components from yeast. We found that Atg9 proteoliposomes first recruited the phosphatidylinositol 3-phosphate kinase complex,最新IF:41.037 官方网址: https://www.sciencemag.org/ 。

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